
이 연구는 인간 뇌에서 반응 억제의 기능적 네트워크, 특히 기저핵의 성공적인 행동 취소에 대한 역할을 조사한다. 메타 분석 결과, 성공적인 억제 과정에서 간접 경로 또는 초단축 경로의 활성화가 관찰되지 않았다. 대신 실패한 정지 시도에서 피질하 영역의 큰 활성화 프로파일이 나타났다.


coremsg

This study investigates the functional network underlying response inhibition in the human brain, particularly the role of the basal ganglia in successful action cancellation. Functional magnetic resonance imaging (fMRI) approaches have frequently used the stop-signal task (SST) to examine this network. We merge five such datasets, using a novel aggregatory method allowing the unification of raw fMRI data across sites. This meta-analysis, along with other recent aggregatory fMRI studies, do not find evidence for the innervation of the hyperdirect or indirect cortico-basal-ganglia pathways in successful response inhibition. What we do find, is large subcortical activity profiles for failed stop trials. We discuss possible explanations for the mismatch of findings between the fMRI results presented here and results from other research modalities that have implicated nodes of the basal ganglia in successful inhibition. We also highlight the substantial effect smoothing can have on the conclusions drawn from task-specific GLMs. First and foremost, this study presents a proof of concept for meta-analytical methods that enable the merging of extensive, unprocessed or unreduced datasets. It demonstrates the significant potential that open-access data sharing can offer to the research community. With an increasing number of datasets being shared publicly, researchers will have the ability to conduct meta-analyses on more than just summary data.

### Competing Interest Statement

The authors have declared no competing interest.

Multi-study fMRI outlooks on subcortical BOLD responses in the stop-signal paradigm

성공적인-반응-억제에-대한-피질하-영역의-역할-재검토-정준-정지-네트워크


성공적인 반응 억제에 대한 피질하 영역의 역할 재검토: 정준 정지 네트워크
