
대식세포에서 Slc30a1은 살모넬라 감염에 대한 숙주 방어에 필수적인 역할을 한다. Slc30a1 결핍은 대식세포의 살균 능력 감소와 세포 내 아연 축적을 통해 살모넬라 감염에 대한 감수성을 증가시킨다.


coremsg

The zinc transporter Slc30a1 plays an essential role in maintaining cellular zinc homeostasis; however, its functional role in macrophages remains largely unknown. Here, we systematically examined the expression and function of Slc30a1 in macrophages upon Salmonella infection in both Slc30a1 reporter mice and in macrophage-specific Slc30a1 knockout ( Slc30a1fl/flLysMCre ) mice. We found that Slc30a1fl/flLysMCre mice have an increased susceptibility to Salmonella infection compared to control littermates. Mechanistically, we found that loss of Slc30a1 in macrophages reduced their bactericidal activity via reduced iNOS and NO production due to intracellular zinc accumulation. In addition, we observed significantly increased expression of Mt1 (metallothionein 1) in Salmonella -infected Slc30a1 -deficient macrophages, suggesting that Mt1 may serve as a compensatory zinc reservoir. Interestingly, macrophages lacking both Mt1 and Slc30a1 expression ( Slc30a1fl/flLysMCre; Mt1-/- ) had increased cell death upon Salmonella infection due to excess zinc-induced oxidative stress. Taken together, our results show that Slc30a1 in macrophages can protect against Salmonella infection, providing mechanistic insights into the role of Slc30a1-mediated zinc homeostasis in macrophages in response to infectious disease.

### Competing Interest Statement

The authors have declared no competing interest.

The zinc transporter Slc30a1 in macrophages plays a protective role against Salmonella infection

살모넬라-감염에-대한-보호-역할을-하는-대식세포의-아연-수송체-slc30a1


살모넬라 감염에 대한 보호 역할을 하는 대식세포의 아연 수송체 Slc30a1
