
등쪽 섬유 전달은 운동 기억 획득 단계에 필수적이지만, 기억 공고화와 회상 단계에는 중요하지 않다.


coremsg

Climbing fiber (CF) transmission from the inferior olivary triggers complex spikes (Cs) in Purkinje cells (PCs) driven by a burst of calcium spikes. In the context of motor learning, especially the compensatory optic response, CF transmission serves as instructive signals selectively conveyed to PCs. While the significance of CF input in motor memory formation is widely acknowledged, a comprehensive understanding of its distinct contribution across different temporal windows, spanning from the initial phase of learning to the retrieval period, remains incomplete. Therefore, we aimed to investigate the necessity of CF-induced instructive signals in motor learning by assessing their roles in memory acquisition, consolidation, and retrieval. We employed optogenetics to selectively inhibit CF transmission during targeted time windows. Consequently, the absence of CF-induced instructive signals during motor learning impairs memory acquisition. However, when these signals were suppressed during the consolidation and retrieval period, there was neither a loss of long-term memory nor prevention of memory retrieval. Our results highlight that CF transmission plays a specialized and critical role primarily in memory acquisition, rather than in subsequent processes.

### Competing Interest Statement

The authors have declared no competing interest.

Acquisition phase-specific contribution of climbing fiber transmission to cerebellum-dependent motor memory

운동-기억-형성에-있어-등쪽-섬유-전달의-획득-단계-특이적-기여


운동 기억 형성에 있어 등쪽 섬유 전달의 획득 단계 특이적 기여
