developing-a-farsi-chatbot-for-self-attachment-technique

大規模言語モデルにおける線形表現の起源について

vehicle-assignment-for-platoon-formation-centralized-vs-distributed-comparison

デジタリティは-長期的な-歴史現象として

pu-ray-domain-independent-point-cloud-upsampling-via-ray-marching-on-neural-implicit-surface

複数の言語モデルを協力してデコードする方法を学ぶ

spike-based-neuromorphic-computing-for-enhanced-computer-vision-insights

decoupled-vertical-federated-learning-fault-tolerant-and-secure-approach


인플루엔자 A 바이러스 M2 단백질은 캐스파아제에 의해 절단되어 M2-LC3 상호작용이 방해되며, 이는 바이리온 생산에 영향을 미친다.


coremsg

Influenza A virus (IAV) Matrix 2 (M2) protein is an ion channel, required for efficient viral entry and egress. M2 interacts with the small ubiquitin-like LC3 protein through a cytoplasmic C-terminal LC3 interacting region (LIR). Here, we report that M2 is cleaved by caspases, abolishing the M2-LC3 interaction. A crystal structure of the M2 LIR in complex with LC3 indicates the caspase cleavage tetrapeptide motif (82SAVD85) is an unstructured linear motif that does not overlap with the LIR. Furthermore, an IAV mutant expressing a permanently truncated M2, mimicking caspase cleavage, is impaired in M2 plasma membrane transport and produces a significantly attenuated virus. Our results reveal a dynamic regulation of the M2-LC3 interaction by caspases. This highlights the role of host proteases in regulating IAV exit, relating virion production with host cell state.

### Competing Interest Statement

The authors have declared no competing interest.

Caspase cleavage of Influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production

인플루엔자-a-바이러스-m2-단백질의-캐스파아제-절단이-m2-lc3-상호작용을-방해하고-바이리온-생산을-조절한다


인플루엔자 A 바이러스 M2 단백질의 캐스파아제 절단이 M2-LC3 상호작용을 방해하고 바이리온 생산을 조절한다


title_rewrite

인플루엔자 A 바이러스 M2 단백질의 캐스파아제 절단과 바이리온 생산 조절