
더 높은 코돈 적응도를 가진 척추동물 종은 더 높은 내재적 구조 무질서를 가진다.


coremsg

The nearly neutral theory of molecular evolution posits variation among species in the effectiveness of selection. In an idealized model, the census population size determines both this minimum magnitude of the selection coefficient required for deleterious variants to be reliably purged, and the amount of neutral diversity. Empirically, an “effective population size” is often estimated from the amount of putatively neutral genetic diversity and is assumed to also capture a species’ effectiveness of selection. A potentially more direct measure of the effectiveness of selection is the degree to which selection maintains preferred codons. However, past metrics that compare codon bias across species are confounded by among-species variation in %GC content and/or amino acid composition. Here we propose a new Codon Adaptation Index of Species (CAIS), based on Kullback-Leibler divergence, that corrects for both confounders. We demonstrate the use of CAIS correlations, as well as the Effective Number of Codons, to show that the protein domains of more highly adapted vertebrate species evolve higher intrinsic structural disorder

### Competing Interest Statement

The authors have declared no competing interest.

The protein domains of vertebrate species in which selection is more effective have greater intrinsic structural disorder

척추동물-체중과-단백질-무질서-경향을-예측하는-새로운-코돈-적응-지표


척추동물 체중과 단백질 무질서 경향을 예측하는 새로운 코돈 적응 지표
