
마이크로프리즘을 이용한 2광자 영상 기법을 통해 마우스 하위 교차 피질의 측면 피질(LC)의 신경화학적 모듈이 다감각 입력의 통제된 통합을 허용한다는 것을 밝혀냈다.


coremsg

To navigate real-world listening conditions, the auditory system relies on the integration of multiple sources of information. However, to avoid inappropriate cross-talk between inputs, highly connected neural systems need to strike a balance between integration and segregation. Here, we develop a novel approach to examine how repeated neurochemical modules in the mouse inferior colliculus lateral cortex (LC) allow controlled integration of its multimodal inputs. The LC had been impossible to study via imaging because it is buried in a sulcus. Therefore we coupled two-photon microscopy with the use of a microprism to reveal the first-ever sagittal views of the LC to examine neuronal responses with respect to its neurochemical motifs under anesthetized and awake conditions. This approach revealed marked differences in the acoustic response properties of LC and neighboring nonlemniscal portions of the inferior colliculus. In addition, we observed that the module and matrix cellular motifs of the LC displayed distinct somatosensory and auditory responses. Specifically, neurons in modules demonstrated primarily offset responses to acoustic stimuli with enhancement in responses to bimodal stimuli, whereas matrix neurons showed onset response to acoustic stimuli and suppressed responses to bimodal stimulation. Thus, this new approach revealed that the repeated structural motifs of the LC permit functional integration of multimodal inputs while retaining distinct response properties.

### Competing Interest Statement

The authors have declared no competing interest.

Microprism-based two-photon imaging of the mouse inferior colliculus reveals novel organizational principles of the auditory midbrain

마우스-하위-교차-피질의-측면-피질에-대한-마이크로프리즘-기반-2광자-영상이-청각-중뇌의-새로운-조직-원리를-밝혀냄


마우스 하위 교차 피질의 측면 피질에 대한 마이크로프리즘 기반 2광자 영상이 청각 중뇌의 새로운 조직 원리를 밝혀냄
