
포유류 난소와 난자에는 생식 수명 전반에 걸쳐 예외적으로 오래 지속되는 단백질, 구조 및 거대분자가 존재한다.


coremsg

The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries and gametes across the reproductive lifespan. Ovaries exhibit localized structural and cell-type specific enrichment of stable macromolecules in both the follicular and extrafollicular environments. Moreover, ovaries and oocytes both harbor a panel of exceptionally long-lived proteins, including cytoskeletal, mitochondrial, and oocyte-derived proteins. The exceptional persistence of these long-lived molecules suggest a critical role in lifelong maintenance and age-dependent deterioration of reproductive tissues.

One sentence summary Exceptionally long-lived macromolecules in mammalian ovaries and oocytes as pillars for lifelong reproductive health span.

### Competing Interest Statement

The authors have declared no competing interest.

Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

포유류-난소와-난자-거대분자의-생식-수명-전반에-걸친-예외적인-장수


포유류 난소와 난자 거대분자의 생식 수명 전반에 걸친 예외적인 장수
