
후측 내측 시상은 선조체 회로에 대한 행동 관련 각성 신호를 제공하여 이후 선택 관련 입력의 효율적 통합을 가능하게 한다.


coremsg

The posterior medial (POm) thalamus is heavily interconnected with sensory and motor circuitry and is likely involved in behavioral modulation and sensorimotor integration. POm provides axonal projections to the dorsal striatum, a hotspot of sensorimotor processing, yet the role of POm-striatal projections has remained undetermined. Using optogenetics with slice electrophysiology, we found that POm provides robust synaptic input to direct and indirect pathway striatal spiny projection neurons (D1- and D2-SPNs, respectively) and parvalbumin-expressing fast spiking interneurons (PVs). During the performance of a whisker-based tactile discrimination task, POm-striatal projections displayed learning-related activation correlating with anticipatory, but not reward-related, pupil dilation. Inhibition of POm-striatal axons across learning caused slower reaction times and an increase in the number of training sessions for expert performance. Our data indicate that POm-striatal inputs provide a behaviorally relevant arousal-related signal, which may prime striatal circuitry for efficient integration of subsequent choice-related inputs.

### Competing Interest Statement

The authors have declared no competing interest.

Role of Posterior Medial Thalamus in the Modulation of Striatal Circuitry and Choice Behavior

후측-내측-시상의-선조체-회로-및-선택-행동-조절에-대한-역할


후측 내측 시상의 선조체 회로 및 선택 행동 조절에 대한 역할
