
The article presents a model for the sequential, multistep activation mechanism of metabotropic glutamate receptor subtype 5, revealing distinct receptor conformations upon agonist, allosteric modulator, and G protein binding.


coremsg

We propose a model for a sequential, multistep activation mechanism of metabotropic glutamate receptor subtype 5, including a series of structures in lipid nanodiscs, from inactive to fully active, with agonist-bound intermediate states.

Stepwise activation of a metabotropic glutamate receptor - Nature

structural-insights-into-the-stepwise-activation-mechanism-of-metabotropic-glutamate-receptor-subtype-5


Structural Insights into the Stepwise Activation Mechanism of Metabotropic Glutamate Receptor Subtype 5
