
Cellular adaptation to cancer therapies involves a progressive resistance continuum driven by dynamic cell-state transitions, metabolic reprogramming, and phenotypic plasticity, which can be targeted to overcome drug resistance.


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Tumour cells adapt to anticancer drug treatments by a series of cellular state transitions, each inducing distinct gene expression programmes and leading to increased drug resistance.

Cellular adaptation to cancer therapy along a resistance continuum - Nature

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Cellular Adaptation to Cancer Therapy: A Dynamic Resistance Continuum Revealed
