
Chromatin interactions in ageing human brain cells impact gene expression and disease pathology.


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We introduce multinucleic acid interaction mapping in single cells (MUSIC), for concurrent profiling of multiplex chromatin interactions, gene expression and RNA–chromatin associations within individual nuclei, as a tool for exploring chromatin architecture and transcription.

Single-cell multiplex chromatin and RNA interactions in ageing human brain - Nature

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Insights into Chromatin and RNA Interactions in Ageing Human Brain
