
Deltex는 Wingless 구배 형성을 촉진하고 전사 효과기 Armadillo/β-catenin의 분해를 통해 Wingless 신호를 길항한다.


coremsg

The Wnt/Wg pathway controls myriads of biological phenomena throughout the development and adult life of all organisms across the phyla. Thus, an aberrant Wnt signaling is associated with a wide range of pathologies in humans. Tight regulation of Wnt/Wg signaling is required to maintain proper cellular homeostasis. Here we report a novel role of E3 ubiquitin ligase Deltex in Wg signaling regulation. Drosophila dx genetically interacts with wg a nd its pathway components. Further, Dx LOF results in a reduced spreading of Wg while its over-expression expands the diffusion gradient of the morphogen. We attribute this change in Wg gradient to the endocytosis of Wg through Dx which directly affects the short and long-range Wg targets. We also demonstrate the role of Dx in regulating Wg effector Armadillo where Dx down-regulates Arm through proteasomal degradation. We also showed the conservation of Dx function in the mammalian system where DTX1 is shown to bind with β-catenin and facilitates its proteolytic degradation, spotlighting a novel step that potentially modulates Wnt/Wg signaling cascade.

### Competing Interest Statement

The authors have declared no competing interest.

E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation

e3-유비퀴틴-리가제-deltex가-wingless-구배를-확장하고-보존된-기전을-통해-전사-효과기-armadillo-β-catenin-분해를-통해-wingless-신호를-길항한다


E3 유비퀴틴 리가제 Deltex가 Wingless 구배를 확장하고 보존된 기전을 통해 전사 효과기 Armadillo/β-catenin 분해를 통해 Wingless 신호를 길항한다
