Reproducible Quantification of Molecules at Ultra-Low Concentrations Using Digital Colloid-Enhanced Raman Spectroscopy with Single-Molecule Counting
Digital (nano)colloid-enhanced Raman spectroscopy enables reproducible quantification of a wide range of target molecules at very low concentrations through single-molecule counting, overcoming the challenges of signal heterogeneity and poor reproducibility faced by conventional surface-enhanced Raman spectroscopy.