
HRF and HRF-reactive IgE play a crucial role in asthma severity and exacerbations, especially in cases induced by rhinovirus (RV) infection.


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Rhinovirus infection is associated with stimulating histamine-releasing factor (HRF) and HRF-reactive immunoglobulin E for increasing severity of asthma and exacerbations.

Asthma Severity, Exacerbations Increase With RV Infection

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Asthma Severity and Exacerbations Linked to RV Infection
