
Functional genomics analysis of an intergenic haplotype on chr21q22 linked to multiple inflammatory diseases reveals ETS2 as a central regulator of human inflammatory macrophages, providing insights into shared disease mechanisms and potential therapeutic opportunities.


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ETS2—which is associated with inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis—is a central regulator of human inflammatory macrophages.

A disease-associated gene desert directs macrophage inflammation through ETS2 - Nature

functional-genomics-reveals-a-disease-associated-gene-desert-regulating-macrophage-inflammation-through-the-ets2-transcription-factor


Functional Genomics Reveals a Disease-Associated Gene Desert Regulating Macrophage Inflammation through the ETS2 Transcription Factor
