
Overexpression of the transcription factor FOXO1 enhances the stem-like phenotype, mitochondrial fitness, persistence, and therapeutic efficacy of CAR T cells against solid tumors.


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Increased effectiveness of anti-cancer chimeric antigen receptor T cell therapy is associated with a stem-like phenotype through increased expression of FOXO1.

FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy - Nature

enhancing-chimeric-antigen-receptor-car-t-cell-stemness-metabolic-fitness-and-efficacy-through-foxo1-overexpression


Enhancing Chimeric Antigen Receptor (CAR) T Cell Stemness, Metabolic Fitness, and Efficacy through FOXO1 Overexpression
