
The Integrator complex uses a multi-step mechanism involving major structural rearrangements to terminate RNA polymerase II transcription by opening the DSIF DNA clamp and preventing Pol II rebinding.


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Cryo-electron microscopy structures of the human Integrator complex in three different functional states shed light on how Integrator terminates RNA polymerase II (Pol II) transcription by disengaging Pol II from the DNA template.

Structural basis of Integrator-dependent RNA polymerase II termination - Nature

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Structural Insights into Integrator-Mediated RNA Polymerase II Termination Mechanism
