
Distinct populations of µ-opioid receptor-expressing neurons in the ventral tegmental area and central amygdala mediate the positive and negative reinforcement effects of fentanyl, respectively.


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Experiments using fentanyl treatment of mice show that µ-opioid receptors mediate positive reinforcement in the ventral tegmental area and negative reinforcement in central amygdala, thereby identifying the circuits that lead to opioid addiction.

Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement - Nature

distinct-neuronal-ensembles-mediate-positive-and-negative-reinforcement-effects-of-fentanyl


Distinct Neuronal Ensembles Mediate Positive and Negative Reinforcement Effects of Fentanyl
