Pathogenic Protein Aggregates Disrupt Clathrin-Mediated Endocytosis and Actin Dynamics, Altering Cellular Mechanics in Neurodegenerative Disorders
Pathogenic protein aggregates, such as those found in Huntington's disease and amyotrophic lateral sclerosis, disrupt clathrin-mediated endocytosis and actin dynamics, leading to altered cellular mechanics that contribute to neurodegeneration.