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Neuronal activity induces actin polymerization in dendritic shafts, which confines AMPA receptor-containing vesicles near sites of stimulation, thereby promoting the delivery of AMPA receptors to synapses undergoing plasticity.


coremsg

AMPA-type receptors (AMPARs) are rapidly inserted into synapses undergoing long-term potentiation (LTP) to increase synaptic transmission, but how AMPAR-containing vesicles are selectively trafficked to these synapses during LTP is not known. Here we developed a strategy to label AMPAR GluA1 subunits expressed from the endogenous loci of rat hippocampal neurons such that the motion of GluA1-containing vesicles in time-lapse sequences can be characterized using single-particle tracking and mathematical modeling. We find that GluA1- containing vesicles are confined and concentrated near sites of stimulation-induced plasticity. We show that confinement is mediated by actin polymerization, which hinders the active transport of GluA1-containing vesicles along the length of the dendritic shaft by modulating the rheological properties of the cytoplasm. Actin polymerization also facilitates myosin-mediated transport of GluA1-containing vesicles to exocytic sites. We conclude that neurons utilize F- actin to increase vesicular GluA1 reservoirs and promote exocytosis proximal to the sites of neuronal activity.

### Competing Interest Statement

Erin K OShea is the President of the Howard Hughes Medical Institute, one of the three founding funders of eLife.

Plasticity-induced actin polymerization in the dendritic shaft regulates intracellular AMPA receptor trafficking

neuronal-activity-induces-actin-polymerization-in-dendritic-shafts-regulating-intracellular-ampa-receptor-trafficking


Neuronal Activity Induces Actin Polymerization in Dendritic Shafts, Regulating Intracellular AMPA Receptor Trafficking


title_rewrite

Regulation of AMPA receptor trafficking by activity-dependent actin polymerization in dendritic shafts