
Interleukin-23 induces the expression of the immunoregulatory checkpoint molecule CTLA-4 on group 3 innate lymphoid cells (ILC3s), which is essential for restraining the pathological outcomes of IL-23 and maintaining intestinal homeostasis.


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Subsets of ILC3s upregulate the immunoregulatory checkpoint molecule CTLA-4 after stimulation in a microbiota-dependent manner, and advances to support CTLA-4+ ILC3s may represent a treatment opportunity in IL-23-driven chronic inflammation.

CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation - Nature

interleukin-23-induces-ctla-4-expression-on-group-3-innate-lymphoid-cells-to-regulate-intestinal-inflammation


Interleukin-23 Induces CTLA-4 Expression on Group 3 Innate Lymphoid Cells to Regulate Intestinal Inflammation
