
Single-molecule sequencing method (HiDEF-seq) can detect single-strand DNA mismatches and damage, providing insights into the initiating events of mutations that lead to cancer and other diseases.


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A DNA sequencing method with single-molecule fidelity detects mismatches and damage present in only one of the two DNA strands with patterns that are both similar and distinct compared to known mutation patterns.

DNA mismatch and damage patterns revealed by single-molecule sequencing - Nature

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Single-Molecule Sequencing Reveals DNA Mismatch and Damage Patterns Underlying Mutations and Disease
