
The human XPR1 transporter plays a critical role in cellular phosphate homeostasis, and its dysfunction is linked to neurodegenerative diseases. This study provides structural insights into the gating and regulation mechanisms of XPR1-mediated phosphate efflux.


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Cryo-electron microscopy structures of human XPR1 in different bound forms reveal the structural basis for XPR1 gating and regulation by inositol polyphosphates.

Human XPR1 structures reveal phosphate export mechanism - Nature

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Structural Insights into the Phosphate Export Mechanism of the Human XPR1 Transporter
