High-Resolution Structure of the Lysosomal Heparan-α-Glucosaminide N-Acetyltransferase (HGSNAT) Reveals Insights into Mucopolysaccharidosis IIIC
The high-resolution cryo-EM structure of the lysosomal membrane protein HGSNAT in complex with acetyl-CoA provides critical insights into the molecular basis of its N-acetyltransferase activity and the impact of mutations that cause the rare lysosomal storage disorder mucopolysaccharidosis IIIC.