
Temperature profoundly affects the structure and function of the temperature-sensitive TRPM4 ion channel, leading to distinct conformations and ligand binding sites at physiological temperatures compared to lower temperatures.


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A temperature-dependent Ca2+-binding site in the intracellular domain of TRPM4 is essential for TRPM4 function in physiological contexts.

Physiological temperature drives TRPM4 ligand recognition and gating - Nature

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Structural and Functional Insights into Temperature-Dependent Regulation of the TRPM4 Ion Channel
