
Dedicated AAA+ ATPase regulators use nucleotide-controlled assembly and DNA deformation to enable structure-based site selectivity, transposase recruitment, and activation for chromosomal rearrangements and dissemination of genetic elements.


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Solution and cryogenic electron microscopy studies using IS21 as a model transposase system show how AAA+ ATPases induce structural changes to prime target DNA and activate their associated transposases.

Molecular basis for transposase activation by a dedicated AAA+ ATPase - Nature

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Molecular Mechanism of Transposase Activation by a Dedicated AAA+ ATPase Regulator
