
The calcium-sensing receptor (CaSR) can activate multiple G-protein subtypes through a common binding mode, facilitated by the receptor's dimeric structure and the flexibility of its intracellular loops.


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Structures of the human calcium-sensing receptor can be bound into complex with G proteins from three different Gα subtypes while maintaining G-protein-binding specificity.

Promiscuous G-protein activation by the calcium-sensing receptor - Nature

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Structural Insights into the Calcium-Sensing Receptor's Ability to Activate Multiple G-Protein Subtypes
